منابع مشابه
CD44: A Multifaceted Molecule in Cancer Progression
CD44, a single pass transmembrane glycoprotein, initially characterized as lymphocyte homing receptor, has now been implicated in various stages of cancer development. The Anomaly in CD44 expression distinguishes most human cancers. CD44 is also identified as cancer stem cell marker. This review will comprehend the versatile role of CD44 during cancer initiation, proliferation, invasion, metast...
متن کاملCell adhesion molecule CD44: its functional roles in prostate cancer.
CD44 is a cell adhesion glycoprotein that also governs cell signaling. Dysregulated CD44 expression characterizes most human cancers, including prostate cancer (PCa). PCa loses expression of CD44 standard (CD44s) that is present in benign epithelium, and overexpresses the novel splice variant (v) isoform, CD44v7-10. We studied CD44 in PCa for more than a decade, and in a series of papers, estab...
متن کاملAdhesion molecule CD44 as a prognostic factor in laryngeal cancer.
BACKGROUND Loss of expression of CD44 has been shown to be a factor of poor prognosis in some types of tumors. The purpose of this study was to analyze this event in relation to the survival of patients with laryngeal cancer. PATIENTS AND METHODS The expression of adhesion molecule CD44 was studied in 137 patients with laryngeal cancer. Data were gathered on clinical (primary tumor location, ...
متن کاملCD44 structure and function.
In this review we discuss the structural elements of CD44 that have been shown to be involved in specific functions. To this end, we focus primarily on experiments in which CD44 constructs are transfected into cells whose function is then assayed. The hyaluronan binding function of CD44 has been assayed in cell lines and in fusion proteins, termed CD44-Igs, consisting of the external domain of ...
متن کاملThe liberation of CD44
CD44 was once thought to simply be a transmembrane adhesion molecule that also played a role in the metabolism of its principal ligand hyaluronan. Investigations of CD44 over the past approximately 20 yr have established additional functions for CD44, including its capacity to mediate inflammatory cell function and tumor growth and metastasis. It has also become evident that intricate posttrans...
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ژورنال
عنوان ژورنال: Atlas of Genetics and Cytogenetics in Oncology and Haematology
سال: 2011
ISSN: 1768-3262
DOI: 10.4267/2042/44676